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KMID : 0358319970380020158
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Korean Journal of Urology
1997 Volume.38 No. 2 p.158 ~ p.166
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Effect of Tamsulosin, a Selective α1A-adrenoreceptor Antagonist, in Benign Prostatic Hyperplasia
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Abstract
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OBJECTIVE:
@EN to evaluate the efficacy and safety of tamsulosin, a selective α1A-adrenoreceptor antagonist in the treatment of urinary outflow obstruction associated with benign prostatic hyperplasia(BPH) in Korean patients.
@ES PATIENTS AND METHODS:
@EN The study was a single-blind and randomized design. Tamsulosin, fixed of 0.2mg was taken once daily for 8 weeks. In control group, terazosin, a non-selective α1-adrenoreceptor antagonist antagonist was administrated with escalating dose of 1
to 5mg
once daily. The study enrolled 98 patients, and 72 patients were included in the analyses at weeks 4 and 8.
@ES RESULTS:
@EN Both tamsulosin and terazosin had similar significant improvements in subjective and objective symptoms of urinary outflow obstruction (P<0.05). Systolic ad diastolic blood pressures decreased significantly in the terazosin-treated patients
(P<0.05). Adverse events, most frequently dry mouth and dizziness, usually mild and transient, were observed significantly more in patients on terazosin (18 patients versus 1 patients on tamsulosin, P<0.001) and led to discontinuation of therapy
in
two
patients on terazosin. )
@ES CONCLUSION:
@EN Tamsulosin, a selective α 1A-adrenoreceptor antagonist, was effective in urinary outflow obstruction associated with BPH. The efficacy of tamsulosin was similar to terazosin. But had a marked better safety profile.
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